Table 3:
Genotype and allele frequencies of two Tim-3 gene promoter SNPs in cases and controls
| Position | Genotype/Allele | Controls n (%) | MS patient n (%) | Odd Ratioa (95% CI) | P-valueb |
|---|---|---|---|---|---|
| −574 A>C | AA | 7(6.9) | 6 (5.9) | 6.067 (1.421–25.9) | 0.0002d |
| CC | 5(4.9) | 26(25.5) | 1:00 (reference)c | ||
| AC | 90(88.2) | 70(68.6) | 6.686 (2.442–18.30) | ||
| A | 104 (50.9) | 82 (40.19) | 1.547 (1.045–2.290) | 0.0367 | |
| C | 100 (49.01) | 122 (59.8) | 1:00 (reference) | ||
| −1516 C>A | AA | 84(82.4) | 73(71.6) | 5.753 (1.601–20.67) | 0.0122 |
| CC | 3(2.9) | 15(14.7) | 1:00 (reference) | ||
| AC | 15(14.7) | 14(13.7) | 5.367 (1.272–22.57) | ||
| A | 183 (89.7) | 160 (78.4) | 2.396 (1.367–4.202) | 0.0027 | |
| C | 21 (10.29) | 44 (21.56) | 1:00 (reference) |
a
Logistic regression analyses were used for calculation odds ratios with 95% confidence interval.
b
Was determined by χ2 test (for genotype) or Fisher exact test (for alleles) from a 2×3 and 2×2 contingency table.
c
The first allele or genotype is considered as reference