Table 1.
Physiological parameters under basal conditions
| Parameter | Control | PT-GS-KO | P Value |
|---|---|---|---|
| Body weight, g | 36.0 ± 1.6 (8) | 41.6 ± 1.4 (14) | <0.05 |
| Food intake, g | 11.6 ± 1.1 (8) | 11.6 ± 0.5 (14) | NS |
| Urine pH | 6.13 ± 0.05 (8) | 6.24 ± 0.05 (14) | NS |
| Urine volume, ml/day | 2.07 ± 0.40 (8) | 2.47 ± 0.23 (14) | NS |
| Urine ammonia, μmol/day | 75 ± 8 (8) | 102 ± 10 (14) | <0.05 |
| Urine titratable acid excretion, μmol/day | 117 ± 26 (8) | 121 ± 12 (14) | NS |
| Serum Na+, mmol/l | 153.6 ± 3.7 (7) | 146.8 ± 0.4 (14) | <0.05 |
| Serum K+, mmol/l | 5.0 ± 0.3 (7) | 4.6 ± 0.2 (14) | NS |
| Serum HCO3−, mmol/l | 15.8 ± 0.9 (7) | 15.6 ± 0.8 (14) | NS |
Values are means ± SE; numbers in parentheses are numbers of animals in each group. PT-GS-KO, proximal tubule-specific glutamine synthetase deletion; NS, not significant. Food was mixed in a 1:1 ratio with water, and the total weight ingested is shown. The actual nutrient intake was 50% of the weight ingested.