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. 2016 Apr 6;310(11):F1197–F1205. doi: 10.1152/ajprenal.00575.2015

Fig. 1.

Fig. 1.

Paraquat (PQ) enhances afferent arteriolar contractions during increases in perfusion pressure (PP) from 40 to 80 mmHg, whereas H2O2 has opposite effects. A: effects of PQ (10−6 mol/l) alone or with pegalated (PEG)-SOD (200 U/ml) or with PEG-catalase (1,000 U/ml) on myogenic contractions. B: effects of H2O2 (10−5 mol/l) alone or with PEG-SOD (200 U/ml) or with PEG-catalase (1,000 U/ml) on myogenic contractions. C: effects of PQ (10−6 mol/l) alone or with H2O2 (10−5 mol/l). D: changes in the ethidium-to-dihydroethidium (E:DHE) fluorescence ratio of afferent arterioles with PQ (10−6 mol/l) alone or with PEG-SOD (200 U/ml) or with PEG-catalase (1,000 U/ml). E: changes in 2′,7′-dichlorodihydrofluorescein diacetate (H2DCFDA) fluorescence of afferent arterioles by H2O2 (10−5 mol/l) alone or with PEG-SOD (200 U/ml) or with PEG-catalase (1,000 U/ml). F: changes in H2DCFDA fluorescence of afferent arterioles by PQ (10−6 mol/l) alone or with PEG-SOD (200 U/ml) or with PEG-catalase (1,000 U/ml). MR, myogenic response. *P < 0.05, **P < 0.01, and ***P < 0.005 compared with vehicle; ††P < 0.01 compared with PQ or H2O2 alone.