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PKC mediates the effects of PQ on myogenic contractions and membrane depolarization and PKG mediates the effects of H2O2. A and C: effects of PQ (10−6 mol/l) and/or Gö6983 (3 × 10−6 mol/l). B and D: effects of H2O2 (10−5 mol/l) and/or Rp-cGMPs (3 × 10−5 mol/l). DiBAC4(3), bis-(1,3-dibutylbarbituric acid)trimethine oxonol. ***P < 0.005 compared with vehicle; ††P < 0.01 and †††P < 0.005 compared with PQ or H2O2 alone.
