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Membrane potential (Em) is reduced by activation of Ca2+-activated Cl− channels (CaCCs) with PP or PQ. DiBAC4(3) fluorescence (A) was increased with PP and PQ (10−6 mol/l) (implying depolarization), but this was blunted by inhibition of CaCCs with CaCCinh-A01 (10−5 mol/l). Luminal diameter (B) was reduced by PP, and this was enhanced by PQ but blunted by CaCCinh-A01. *P < 0.05 and ***P < 0.005 compared with vehicle; †††P < 0.005 compared with PQ alone.
