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Presumed mechanisms of DMF action in MS.
DMF may exert immunomodulatory as well as cytoprotective effects via activation of Nrf2 mediated or HCAR2-mediated signalling pathways.
DMF, dimethyl fumarate; HCAR2, hydroxycarboxylic acid receptor 2; MS, multiple sclerosis; Nrf2, nuclear factor (erythroid derived 2)-like2 transcription factor.
