Table 3. The SNPs nominally associated with pre-eclampsia in the analysis in the combined FINNPEC and SISu data set.
Gene | rs number | A2 | MAF PE case | MAF non-PE ctrl | MAF SISu | MAF SISu + non-PE ctrl | P* | OR (CI 95%)* |
---|---|---|---|---|---|---|---|---|
TP53BP1 | rs3803339 | G | 0.046 | 0.038 | 0.035 | 0.035 | 0.0058 | 1.33 (1.09–0.63) |
ZFR2 | rs61747120 | T | 0.066 | 0.067 | 0.054 | 0.055 | 0.0237 | 1.22 (1.03–1.44) |
ANO9 | rs113926353 | G | 0.036 | 0.038 | 0.045 | 0.044 | 0.0477 | 0.80 (0.64–1.00) |
TMTC1 | rs142394560 | A | 0.040 | 0.031 | 0.032 | 0.032 | 0.0477 | 1.25 (1.00–1.57) |
*Pre-eclamptic cases compared to the combined control data (the non-pre-eclamptic FINNPEC controls + the SISu (3.0) data, in which information on pre-eclampsia was not available). A2 = minor allele; MAF = minor allele frequency; PE = pre-eclampsia; SISu = Sequencing Initiative Suomi; OR = odds ratio; CI = confidence interval.