Table 3. Characteristics of 13 studies evaluating the effect of statins on Biochemical Recurrence-Free Survival.
| Sources (year) | Primary treatment(s) | No. of patients | Biochemical Recurrence-Free Survival Rate |
|---|---|---|---|
| Duration: Statins users (%) vs Non-statin users (%); P-value | |||
| Katz et al. (2003)37 | RT# | 905 | 5 year: 88.8% vs 71.2%; P = .009 |
| Moyad et al. (2006)8 | RT | 938 | 9 year: 98.4% vs 95.2%; P = 0.062 |
| Shippy et al. (2007)38 | RT | 871 | 10-year: 76% vs 66%; P = 0.01 |
| Soto et al. (2009)9 | RT | 968 | 5 year: 67% vs 57%; P = 0.03 |
| Gutt et al. (2010)11 | RT | 691 | 4 year: 93% vs 80%; P < 0.001 |
| Kollmeier et al. (2011)14 | RT | 1711 | 5 year: 89% (95%CI, 85–92%) vs 80% (95%CI, 72–86%) 8 year: 83% (95%CI, 81–85%) vs 74% (95%CI, 71–77%) |
| Ritch et al. (2011)17 | RP$ | 1261 | 5 year: 75% vs 84%; P < 0.05 |
| Misrai et al. (2012)39 | RP | 377 | 2 year: 93% vs 88%; P = 0.16 |
| Rieken et al. (2013)20 | RP | 6842 | 2 year: 94 ± 1% vs 92 ± 0%; P = NR* 5 year: 84 ± 1% vs 82 ± 1%; P = NR 10 year: 71 ± 3% vs 66 ± 3%; P = NR |
| Caon et al. (2014)36 | RT ± ADT | 3851 | 10-year: 94.1% vs 91.2%; P = 0.031 |
| Oh et al. (2014)25 | RT | 247 | 5 year: 97.2% vs 89.6%; P = 0.007 |
| Cuaron et al. (2015)40 | RT | 754 | 8-year: 84.5% vs 88.2%; P = 0.85 |
| Danzig et al. (2015)29 | RP | 767 | 2-year: 79.0% vs 79.3%; P = NR 5-year: 63.7% vs 72.4%; P = NR |
*NR, not report.
#RT, radiation therapy.
$RP, radical prostatectomy.