Table 1.
RIFLE, AKIN, and KDIGO classification for AKI diagnosis.
| RIFLE | AKIN | KDIGO | Urine output∗ | |||
|---|---|---|---|---|---|---|
| Criteria | Creatinine definition | Criteria | Creatinine definition | Criteria | Creatinine definition | |
| Risk | ≥1.5-fold increase from baseline SCr or decrease in GFR ≥25% |
Stage 1 | ≥0.3 mg/dL increase or ≥1.5-fold increase from baseline SCr within 48 hrs | Stage 1 | ≥0.3 mg/dL increase within 48 hrs or 1.5–1.9 times baseline within 7 days | <0.5 mL/kg/h for >6 hours |
|
| ||||||
| Injury | ≥2-fold increase from baseline SCr or decrease in GFR ≥50% |
Stage 2 | ≥2-fold increase from baseline SCr | Stage 2 | 2.0–2.9 times baseline within 7 days | <0.5 mL/kg/h for 12 hours |
|
| ||||||
| Failure | ≥3-fold increase from baseline SCr or increase to ≥4 mg/dL or decrease in GFR ≥75% |
Stage 3 | ≥3-fold increase from baseline SCr or increase to ≥4.0 mg/dL with an acute increase of >0.5 mg/dL or initiation of RRT |
Stage 3 | ≥3 times baseline within 7 days or increase to ≥4.0 mg/dL with an acute increase of >0.5 mg/dL or initiation of RRT |
<0.3 mL/kg/h for 24 hours or anuria for >12 hours |
RIFLE: risk, injury, failure, loss, end-stage kidney disease; AKIN: acute kidney injury network; KDIGO: kidney disease: improving global outcomes; SCr: serum creatinine; GFR: glomerular filtration rate; RRT: renal replacement therapy.
∗Urine output criteria are common to three definitions.