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. Author manuscript; available in PMC: 2017 Aug 1.
Published in final edited form as: J Immunol. 2016 Jun 24;197(3):934–941. doi: 10.4049/jimmunol.1600581

Figure 6. Enhanced ERK signaling is associated with the hyperresponsiveness of DGKζ KO NK cells.

Figure 6

WT or DGKζ KO splenocytes were stimulated with plate-bound anti-NK1.1 antibody in the presence of various concentrations of the MEK inhibitor U0126. A) The proportion of NK cells (CD3−DX5+NKp46+) incorporating anti-CD107a antibody is shown. B) The percentage of responding cells as compared to no drug control (% of baseline) is plotted. N=3–5 per concentration. *** = P<0.001, NS= not significant by 2 way-ANOVA. Data shown is complied from at least 3 independent experiments.