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. Author manuscript; available in PMC: 2017 Aug 1.
Published in final edited form as: J Immunol. 2016 Jun 24;197(3):934–941. doi: 10.4049/jimmunol.1600581

Figure 8. DGKζ KO NK cells are more effective at effectively clearing TAP-deficient tumor cells.

Figure 8

A) RMA-S tumor cells were injected s.c. into WT or DGKζ KO mice. 12 days later, the tumors were harvested and weighed. One representative of 2 independent experiments is shown. B) NK cell-sufficient (left) or NK cell-depleted (right) WT or DGKζ KO mice were injected i.v. with a mixture of CFSE-labeled RMA and Celltrace Violet-labeled RMAS-S tumors. 18 hours later, splenocytes were analyzed for the presence of residual tumor cells via flow cytometry. The ratio of RMA-S versus RMA within each WT or DGKζ KO mouse was calculated and shown as a scatter plot. One representative of 2 independent experiments is shown. *, ** and *** represent a statistical significance by Student’s t-test of p<0.05, p<0.01 and p<0.001 respectively. NS = not significant.