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. 2016 Jul 7;6:28711. doi: 10.1038/srep28711

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Copyright © 2016, Macmillan Publishers Limited

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PrP-seeding activity was measured in sCJD (MM1) CSF samples (n = 14), treated with doxycycline at different time points during the RT-QuIC analysis. 0.5 mM doxycycline was added either at the beginning of the run (t = 0) or at 24 (t = 24), 48 (t = 48) or 72 hours (t = 72) after the run had been started. Early addition of doxycycline resulted in a complete inhibition of PrP-seeding activity. Non-treated reactions were used as a reference (Ref). A p-value: <0.001 as extremely significant (***), <0.01 as very significant (**), <0.05 as significant (*) and ≥0.05 as not significant (ns).