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. 2016 Jul 7;6:28851. doi: 10.1038/srep28851

Table 4. Time Lapse Key Pathways.

Time lapse Selected Processes Result Ref (e.g.)
6 v 0 Decrease in cytokine signaling Certain cytokines block adipogenesis 19,20,67
Differential transcription factor regulation Cell cycle arrest, promotion of adipogenesis 76, 77, 78, 79
48 v 6 IL signalling pathways Signalling through JAK/STAT 67,100
Peroxisome & UnsatFA synthesis Fatty acid metabolism 101
Prolactin receptor signalling Regulation of glucose/lipid & transporters 95
Pathogenic E. coli Changes in cytoskeletal structures 81, 82, 83
PPAR-γ pathway Nuclear receptor signalling 74,80,91
NOTCH2,3,4 Signalling 102,103
TGF-β Signalling 104
Integrin Extracellular matricx 85,105
96 v 48 PPAR-γ pathway PPAR signalling 74,91
Focal adhesion/integrin Cell remodelling 92
Insulin signalling Insulin responsiveness 84
Leptin & adipokine Adipokine signaling 67,98
Unsaturated fatty acid synthesis Fatty acid metabolism 101
Glyoxlate, dicarboxylate, glycine, serine, threonine Precursors including for fatty acid biosynthesis  
NOTCH, TGFB, TRIAL, CTCF Cell signalling 102,103
Citrate and TCA cycle Changes in energy metabolism 97
Syndecan Link ECM to signalling pathways 106
P53 pathway Cell cycle control 107
192 v 96 WNT signalling Coupling signalling to transcription 93,94
Insulin signalling Insulin responsiveness 84
Glucose metabolism Changes in energy metabolism 94
PPAR signalling PPAR signalling 74,91
FOXM1 Multipl with DNA repair 108
Peroxisome, FA metabolism Fatty acid metabolism 101
IL5, ERK, ILK, P53 Cell signaling  
Porphyrin metabolism Linked to WNT signaling 96
Regulation of pyruvate dehydrogenase, Citrate & TCA cycle Changes in energy metabolism 97
Syndecan Link ECM to signalling pathways 106
Branched chain amino acid Lipid biosynthesis 109
384 v 192 Na independent glucose transporters Increased glucose & fructose uptake  
FRA Pathway Transcriptional regulations 98,110
Integrin 4 Basement membrane structure 105
NGF and Toll Cell signaling 111
IGF1 Pathway Adipose regeneration 112
Insulin signalling Insulin responsiveness 84
Cardiaegf Calcium regulation 113