Figure 2. Comparison of somatic alterations between paired tumours.

(a) Clonality of putative driver alterations in cancer genes that are shared between paired tumours. Alteration clonality corresponds to the fraction of cancer cells carrying the alteration (see Methods section). Tumours of patient UH6 are not shown because they did not share any altered cancer genes (Supplementary Data 4). (b,c) Similarity matrix of all altered genes (b) and of altered cancer genes (c) across the 20 syCRCs. For each pair of tumours from same or different patients, the Jaccard coefficient was measured as the proportion of shared altered genes over the total number of altered genes.