Table 1. Patient characteristics.
| Patient characteristics | Number (%) | Univariate analysis | Multivariate analysis |
|---|---|---|---|
| No. of patients | 84 (100) | ||
| Age (years) | P=0.886 | ||
| Median | 48.7 | ||
| >60 | 8 (9) | ||
| <60 | 76 (91) | ||
| Sex | P=0.538 | ||
| Male | 46 (55) | ||
| Female | 38 (45) | ||
| Diagnosis | P=0.786 | ||
| De novo AML | 67 (80) | ||
| sAML | 17 (20) | ||
| Cytogenetic risk (ELN) | P=0.125 | ||
| Favorable | 9 (11) | ||
| Intermediate I | 16 (19) | ||
| Intermediate II | 25 (30) | ||
| Adverse | 34 (40) | ||
| Stage at transplantation | P=0.005 | P=0.292 | |
| First CR | 13 (15) | ||
| Second CR | 12 (14) | ||
| Primary refractory | 31 (37) | ||
| Refractory relapse | 28 (34) | ||
| Extramedullary disease | 24 (29) | P<0.001 | P=0.981 |
| Time | |||
| Present at transplantation | 17 | P<0.001 | P=0.008 |
| Present at relapse after transplantation | 4 | ||
| Present at first relapse before transplantation | 1 | ||
| Only present at diagnosis | 1 | ||
| Localized | |||
| Chloroma | 7 (25) | ||
| Meningeosis | 16 (67) | ||
| Chloroma and meningeosis | 2 (8) | ||
| GvHD | |||
| cGvHD | 32 (38) | ||
| Skin | 21 (25) | ||
| Gastrointestinal | 11 (13) | ||
| aGvHD | 44 (52) | ||
| Skin | 19 (22) | ||
| Gastrointestinal | 25 (30) | ||
| Donor | P=0.984 | ||
| Family donor | 16 (19) | ||
| Unrelated donor | 56 (67) | ||
| Unrelated HLA-mismatch donor | 12 (14) | ||
| Prior transplantation | 5 | ||
| Allogeneic HSCT | 4 | ||
| Autologous HSCT | 1 | ||
| Cause of death | |||
| Leukemia related | 34 (57) | ||
| Non-leukemia mortality | 22 (37) | ||
| Unknown | 4 (6) | ||
Abbreviation: ELN, European Leukemia Network.
Bold entries represent P<0.05.