Table 1.
Five-year cumulative incidences of death among patients with melanoma
| Cause-specific death | Death from other causes | |||||
|---|---|---|---|---|---|---|
| Characteristics | N (%) | Event | 5-year (%) | P | 5-year (%) | P |
| Total | 40043 | 7216 | 7.1 (6.8 to 7.3) | 7.4 (7.1 to 7.6) | ||
| Age (years) | < 0.001 | < 0.001 | ||||
| 20–39 years | 5940 (14.8) | 262 | 3.3 (2.8 to 3.7) | 0.4 (0.3 to 0.6) | ||
| 40–64 years | 20766 (51.9) | 2069 | 5.7 (5.4 to 6.0) | 2.3 (2.1 to 2.5) | ||
| 65+ years | 13337 (33.3) | 4885 | 10.8 (10.3 to 11.3) | 18.2 (17.5 to 18.9) | ||
| Sex | < 0.001 | < 0.001 | ||||
| Male | 22295 (55.7) | 4901 | 8.7 (8.3 to 9.1) | 8.9 (8.5 to 9.3) | ||
| Female | 17748 (44.3) | 2315 | 5.0 (4.7 to 5.3) | 5.4 (5.1 to 5.8) | ||
| Race | < 0.001 | 0.006 | ||||
| White | 39559 (98.8) | 7075 | 6.9 (6.6 to 7.1) | 7.4 (7.1 to 7.7) | ||
| Non-white | 484 (1.2) | 141 | 20.7 (17.2 to 24.4) | 4.2 (2.7 to 6.3) | ||
| Melanoma subtype | < 0.001 | < 0.001 | ||||
| Superficial spreading melanoma | 13444 (33.6) | 1645 | 3.9 (3.6 to 4.2) | 5.4 (5.0 to 5.8) | ||
| Nodular melanoma | 2875 (7.2) | 1233 | 25.6 (24.0 to 27.2) | 12.1 (10.9 to 13.3) | ||
| Lentigo maligna melanoma | 2383 (6.0) | 547 | 3.4 (2.7 to 4.2) | 14.5 (13.1 to 16.0) | ||
| Melanoma, NOS | 18926 (47.3) | 3131 | 6.2 (5.9 to 6.5) | 6.9 (6.5 to 7.3) | ||
| Others | 2415 (6.0) | 660 | 12.8 (11.5 to 14.2) | 9.2 (8.1 to 10.4) | ||
| Anatomic sites | < 0.001 | <0.001 | ||||
| Extremities | 18427 (46.0) | 2811 | 5.9 (5.6 to 6.3) | 6.2 (5.9 to 6.6) | ||
| Trunk | 13987 (34.9) | 2250 | 6.9 (6.5 to 7.3) | 5.9 (5.5 to 6.3) | ||
| Face and ears | 4819 (12.0) | 1331 | 8.0 (7.2 to 8.8) | 13.8 (12.8 to 14.8) | ||
| Scalp and neck | 2810 (7.0) | 824 | 13.9 (12.6 to 15.2) | 10.8 (9.6 to 11.9) | ||
| Thickness (mm) | < 0.001 | < 0.001 | ||||
| ≤ 1.00 | 28017 (70.0) | 3086 | 2.2 (2.0 to 2.4) | 5.9 (5.7 to 6.3) | ||
| 1.01–2.00 | 6279 (15.7) | 1415 | 9.4 (8.7 to 10.2) | 8.1 (7.5 to 8.8) | ||
| 2.01–4.00 | 3464 (8.9) | 1391 | 21.2 (19.9 to 22.6) | 11.8 (10.8 to 12.9) | ||
| > 4.00 | 2283 (5.7) | 1324 | 38.1 (36.1 to 40.1) | 15.2 (13.7 to 16.7) | ||
| Ulceration | < 0.001 | < 0.001 | ||||
| Absent | 35065 (87.6) | 4916 | 4.1 (3.9 to 4.3) | 6.6 (6.3 to 6.8) | ||
| Present | 4978 (12.4) | 2300 | 27.6 (26.4 to 28.9) | 12.8 (11.9 to 13.8) | ||
| Lymph node status | < 0.001 | < 0.001 | ||||
| N0 | 37363 (93.3) | 5889 | 4.8 (4.6 to 5.0) | 7.4 (7.1 to 7.7) | ||
| N1 | 1543 (3.9) | 650 | 31.0 (28.7 to 33.4) | 6.0 (4.9 to 7.3) | ||
| N2 | 762 (1.9) | 401 | 38.8 (35.5 to 42.3) | 7.8 (6.0 to 9.9) | ||
| N3 | 375 (0.9) | 276 | 63.8 (58.7 to 68.5) | 6.2 (4.0 to 8.9) | ||
| Stage | <0.001 | < 0.001 | ||||
| I/II | 37363 (93.3) | 5889 | 4.8 (4.6 to 5.0) | 7.4 (7.1 to 7.7) | ||
| III | 2680 (6.7) | 1327 | 37.8 (36.0–39.7) | 6.5 (5.7–7.5) | ||
Abbreviation: NOS malignant melanoma, not otherwise specified