TABLE 1.
Usage of alanine codons in human mitochondrial genes and relative polypeptide levels in mutant cell lines
| Polypeptide | No. of amino acids | No. of alanine residues | Alanine codon density (%) | Avg polypeptide level in mutants (% of controls)a |
|---|---|---|---|---|
| ND1 | 318 | 27 | 8.5 | 47.2 |
| ND4 | 459 | 26 | 5.7 | 97.6 |
| CO2 | 227 | 14 | 6.1 | 69.4 |
| ND6 | 174 | 8 | 4.6 | 82.1 |
| CYTB | 378 | 25 | 6.6 | 78.9 |
| ATP6 | 226 | 19 | 8.4 | 56.5 |
| CO1 | 513 | 40 | 7.8 | |
| ND5 | 603 | 44 | 7.3 | |
| CO3 | 260 | 15 | 5.7 | |
| ND2 | 347 | 20 | 5.8 | |
| ND3 | 115 | 8 | 1 | |
| ND4L | 98 | 9 | 1 | |
| ATP8 | 68 | 0 | 0 |
a
Values are the average levels of the individual polypeptide in the mutant cell lines relative to levels in the control cell lines.