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. 2016 Jul 7;18:157. doi: 10.1186/s13075-016-1059-1

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© The Author(s). 2016

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 7 — Mechanistic network derived from differential gene expression analysis using IPA and comparing untreated JIA to healthy controls. Nodes in orange reflect predicted activation, while those in blue are predicted to be inhibited based on the patterns of differential gene expression. Suppression of TLR9-regulated networks is predicted from this analysis