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. 2016 Jul 7;16:418. doi: 10.1186/s12885-016-2424-9

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© The Author(s). 2016

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 2 — Muscle proteins are mainly degraded by proteasome pathway in Walker 256 tumour-bearing rats and metformin modulates this via. Enzyme activity of three different protein degradation pathways was analysed: (a) calcium-dependent pathway, (b and c) lysosomal pathway and (d) ubiquitin-proteasome pathway. Metformin modulates chymotrypsin-like activity in Walker 256 tumour-bearing rats bring the value close to C. Legend: C, control rats; W, Walker 256 tumour-bearing rats; M, metformin-treated rats (33 mg/Kg); WM, Walker 256 tumour-bearing rats treated with metformin (33 mg/Kg). Number of animals per group = 8. Columns represent mean ± SD. *p < 0.05 vs C; #p < 0.05 vs W