TABLE 1.
Predicted functions of ted cluster genes
| Name | Description of gene and/or gene producta |
|---|---|
| tedX1 | 4′-PPT |
| tedX2 | 3′,5′-Cyclic AMP phosphodiesterase, CpdA-like protein |
| tedX3 | Lantibiotic cyclase, lanC-like gene |
| tedX4 | Lantibiotic dehydratase, thiopeptide-type bacteriocin biosynthesis domain |
| tedX5 | Small peptide |
| tedF1 | Tetronate ring tailoring enzyme, fkbH-like gene |
| tedF2 | Tetronate ring tailoring enzyme, fkbH-associated ACP |
| tedB | Thioesterase |
| tedS1 | Polyketide synthase (ATAc-ACP, KS-ATmal-DH-KR-ACP, KS-ATmal-DH-KR-ACP) |
| tedS2 | Polyketide synthase, docking domain (KS-ATmal-DH-ER-KR-ACP) |
| tedM | Major facilitator superfamily (MFS) efflux pump |
| tedL | Large ATP-binding luxR (LAL)-type regulator |
| tedC | Flavin reductase, potentially uses the coenzyme F420 |
| tedR | Streptomyces antibiotic regulatory protein (SARP)-type regulator |
| tedD | FMN-linked alkanal monooxygenase, potentially uses F420 |
| tedE | FMN-linked alkanal monooxygenase, potentially uses F420 |
| tedA4 | ABC transporter, ATP-binding protein |
| tedA3 | ABC transporter, permease |
| tedA2 | ABC transporter, permease |
| tedA1 | ABC transporter, substrate-binding protein |
| tedG | Ferredoxin |
| tedH | Cytochrome P450 |
| tedF3 | Tetronate ring tailoring enzyme, acyltransferase |
| tedF4 | Tetronate ring tailoring enzyme, hydrolase |
| tedI | F420-dependent oxidoreductase |
| tedJ | Short-chain dehydrogenase/reductase |
| tedF5 | Tetronate ring tailoring enzyme, fabH-like gene |
| tedU | Predicted protein, conserved domain DUF4157 |
| tedS3 | Polyketide synthase, docking domain (KS-ATmal-DH-ER-KR-ACP, KS-ATmmal-DH-KR-ACP) |
| tedS4 | Polyketide synthase, docking domain (KS-ATmal-ACP) |
| tedT | tetR family regulator |
| tedX6 | Thioesterase |
a
Function was annotated by searching the protein sequence for conserved domains in the NCBI Conserved Domain Database or, for the PKS genes, with the use of antiSMASH. PPT, phosphopantetheine transferase; FMN, flavin mononucleotide; ATAc, acetyl coenzyme A acyltransferase; DH, dehydratase; KR, ketoreductase; KS, ketosynthase; ATmal, malonyl coenzyme A acyltransferase; ER, enoyl reductase; ATmmal, methylmalonyl coenzyme A acyltransferase; ABC, ATP-binding cassette.