TABLE 2.

HCV-regulated miRNAs with known involvement in inflammation, fibrosis, and cancer^a

miRNA ID	miRNA target (gene symbol)	Molecular function in:
		Inflammation	Fibrosis	Cancer
miR-122-5p	IGF1R	×	×	×
	SRF	×	×	×
	CCNG1			×
	SLC7A1			×
	BCL2L2	×
	ADAM10	×	×	×
	PRKRA
	WNT1	×	×	×
miR-210-3p	FGFRL1			×
	RAD52		×	×
	EFNA3			×
	BDNF	×	×	×
	PTPN1	×
	ISCU			×
	E2F3			×
	MNT	×	×	×
miR-338-5p	LRP1	×		×
miR-483-3p	SMAD4	×	×	×
	BBC3			×
	SRF	×	×	×
	MAPK3			×
miR-574-5p	FOXN3			×
miR-885-5p	CDK2		×	×
	MCM5			×
miR-1	HCN4	×
	FOXP1			×
	HCN2	×	×
	PTMA			×
	MET	×	×	×
	XPO6			×
	TAGLN2	×	×	×
	LASP1	×		×
	KCNE1			×
	PNP			×
	PIM1	×		×
	PAX3			×
	TWF1		×	×
	TWF2
	FN1	×		×
	NOTCH3	×	×
	FABP3		×	×
miR-10a-5p	HOXA1	×		×
	USF2		×	×
	MAP3K7	×		×
	BTRC
	EPHA4	×		×
miR-127-3p	PRDM1	×		×
	BCL6	×		×
miR-132-3p	CDKN1A	×	×	×
	ARHGAP32
	RB1	×		×
	HBEGF	×	×	×
miR-133b	KCNH2			×
	FSCN1			×
	FAIM			×
	EGFR	×	×	×
	FGFR1	×	×	×
	HCN4	×
miR-143-3p	KRAS	×	×	×
	MYO6			×
	DNMT3A	×	×	×
	FNDC3B			×
	MAPK7			×
	FSCN1			×
	SERPINE1	×	×	×
	MACC1	×		×
	JAG1	×	×	×
	AKT1	×	×	×
miR-146a-5p	CXCR4	×	×	×
	TLR2	×	×	×
	TRAF6	×		×
	IRAK1	×		×
	BRCA1	×		×
	NFKB1	×		×
	EGFR	×	×	×
	CD40LG	×	×	×
	SMAD4	×	×	×
	HNF1	×	×	×
	SHP1	×	×	×
	TLR4	×	×	×
miR-150-5p	MYB	×	×	×
	EGR2	×		×
	MUC4	×	×	×
	ZEB1	×	×	×
miR-206	MET	×	×	×
	NOTCH3	×	×
	ESR1	×		×
	PAX3			×
miR-212-3p	MECP2	×	×	×
	PEA15			×
	PTCH1		×	×
	RB1	×		×
miR-21-5p	RASGRP1			×
	BCL2	×	×	×
	TIMP3	×	×	×
	SOX5			×
	MTAP	×	×	×
	RECK		×	×
	TGFBR2	×	×	×
	PTEN	×	×	×
	E2F1	×	×	×
	LRRFIP1	×		×
	TPM1			×
	NFIB			×
	APAF1	×		×
	BTG2			×
	PDCD4	×	×	×
	RHOB	×		×
	SERPINB5		×	×
	BMPR2	×	×	×
	DAXX	×		×
	TP63			×
	MSH2	×		×
	MSH6			×
	ISCU			×
	EIF4A2			×
	ANKRD46			×
	CDK2AP1			×
	DUSP10			×
	PPARA	×	×	×
	ANP32A			×
	SMARCA4			×
	FASLG	×	×	×
miR-494-3p	PTEN	×	×	×
	CDK6	×		×
	BCL2L11			×
miR-584-5p	ROCK1	×	×	×
miR-663a	JUNB	×		×
	JUND			×

^a The targets of miRNAs differentially regulated by HCV infection in hepatocyte-like Huh7.5.1 cells at 7 days postinfection were retrieved using the miRsystem tool. The involvement of these target genes in pathways related to inflammation, fibrosis, and cancer was assessed through miRsystem and a systematic screen of the available literature by use of PubMed. ×, involvement of miRNA target in the indicated process.