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. 2016 Jun 24;90(14):6244–6254. doi: 10.1128/JVI.00144-16

FIG 1.

FIG 1

Monitoring PrPSc refolding after GdnHCl-induced unfolding. Samples were exposed to increasing concentrations of GdnHCl and then PK digested immediately (upper panel) or after GdnHCl dilution (lower panel). PrPSc refolding is detected after GdnHCl dilution in samples exposed to up to 2.5 M GdnHCl.