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HPV16 Infectivity is proportional to furin cleavage. (A) Cleavage blot from mock- or PSTCD-L2 infected furin-deficient FD11 or furin-secreting FurΔ1 cells in the presence of DMSO or the furin inhibitor dRVKR. (B) PSTCD-L2 infectivity plotted as a function of L2 cleavage. (C) Cleavage blots of PSTCD-L2 virus incubated overnight at 37°C in FD11 or FurΔ1 CCM, followed by infection of HaCaT cells, again in the presence of either FD11 or FurΔ1 CCM.
