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CsA has a minimal effect on cleavage of L2 containing an unmodified N terminus. Shown are representative cleavage blots of L2-HA infected HaCaT cells in the presence of DMSO carrier, furin inhibitor dRVKR, or cyclophilin inhibitor CsA. Replicates (reps) 1 to 5 used dRVKR and CsA at 25 μM and 10 μM, respectively. Replicate 6 used dRVKR and CsA at 2.5 μM and 5 μM, respectively.
