FIG 4.

The contribution of CD151 to HCMV infection was not cell type restricted. (A and B) Relative fractions of HCMV-infected HEC-LTTs (A) or HFFs (B) as measured by immunofluorescence staining of immediate early antigens. Cells were transfected with a pool of CD151 siRNAs or control siRNAs, as indicated, 48 h prior to infection. NT siRNA-treated cells served as a reference, and IE siRNA was used as a positive control. (A) HEC-LTTs were infected with HCMV strain TB40/E. (B) HFFs were infected with a highly endotheliotropic (TB40/E) or poorly endotheliotropic (TB40/F) strain. Error bars show standard errors of the means. *, significant (P < 0.05; Student's t test).