TABLE 1.
Pro- and antiviral genes identified in the RNAi screen
| Gene category and name | Relative IE expression (rel. OD492)a | SD | P value | Gene description/full gene name | Other name(s) | Classification |
|---|---|---|---|---|---|---|
| Proviral genes | ||||||
| CXCR5 | 0.68 | 0.12 | 0.00010 | Chemokine (C-X-C motif) receptor 5 | BLR1, CD185, MDR15 | Chemokine receptor |
| ITGB4 | 0.68 | 0.09 | 0.00002 | Integrin beta 4 | CD104 | Integrin |
| CD151 | 0.72 | 0.17 | 0.00240 | CD151 molecule (Raph blood group) | GP27, MER2, RAPH, SFA1, PETA-3, TSPAN24 | Tetraspanin |
| CCRL2 | 0.73 | 0.07 | 0.00001 | Chemokine (C-C motif) receptor-like 2 | HCR, CKRX, CRAM, ACKR5, CCRL2, CRAM-A, CRAM-B | Chemokine receptor |
| ITGA11 | 0.74 | 0.09 | 0.00007 | Integrin alpha 11 | HsT18964 | Integrin |
| Antiviral genes | ||||||
| CD34 | 1.11 | 0.08 | 0.00837 | CD34 molecule | Adhesion molecule | |
| GPR126 | 1.13 | 0.09 | 0.00446 | Adhesion G protein-coupled receptor G6 | ADGRG6, APG1, DREG, VIGR, PS1TP2 | Adhesion molecule |
| FLT1 | 1.17 | 0.12 | 0.00522 | Fms-related tyrosine kinase 1 | FLT, FLT-1, VEGFR1, VEGFR-1 | Growth factor receptor |
| EGFR | 1.19 | 0.15 | 0.00798 | Epidermal growth factor receptor | ERBB, HER1, mENA, ERBB1, PIG61, NISBD2 | Growth factor receptor |
| CCR4 | 1.20 | 0.17 | 0.01131 | Chemokine (C-C motif) receptor 4 | CKR4, K5-5, CD194, CMKBR4, ChemR13, CC-CKR-4, HGCN:14099 | Chemokine receptor |
| ENG | 1.22 | 0.23 | 0.03337 | Endoglin | END, HHT1, ORW1, CD105 | Glycoprotein, growth factor coreceptor |
| KDR | 1.25 | 0.21 | 0.01120 | Kinase insert domain receptor | FLK1, CD309, VEGFR, VEGFR2 | Growth factor receptor |
| FGFR1 | 1.30 | 0.20 | 0.00381 | Fibroblast growth factor receptor 1 | CEK, FLG, HH2, OGD, FLT2, KAL2, BFGFR, CD331, FGFBR, FLT-2, HBGFR, N-SAM, FGFR-1, HRTFDS, bFGF-R-1 | Growth factor receptor |
a
rel. OD492, relative optical density at 492 nm.