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. 2016 Jul 7;13:48. doi: 10.1186/s12977-016-0279-4

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© The Author(s) 2016

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 1 — Development of heterologous and autologous NAb responses in elite neutralizer D16916. a Neutralizing activity over the course of HIV-1 infection against the individual viruses of a 6-virus panel that is representative for HIV-1 variation worldwide [8, 32]. The ID₅₀ against each virus as well as the geometric mean midpoint titer for all 6 viruses combined are given for D16916 sera taken 8, 11, 14, 19, 22, 26, 30, 34 and 38 months post-SC. A color scale is used to indicate low (green) to high (red) ID₅₀ values. b Longitudinal neutralization of autologous viruses. The mean ID₅₀ values of longitudinal sera (x-axis) against the autologous viruses (3 for month 7 and 6 for month 11, all in grey) are plotted in green (month 7) and blue (month 11). The red line indicates the geometric mean midpoint titer against the heterologous 6-virus panel from a [14]