Table 2.
N332-directed heterologous NAb responses in elite neutralizer D16916
| ID50 a | Foldd reduction | ||
|---|---|---|---|
| WTb | N332A | ||
| 92BR020 | 1711 | 49 | 35 |
| JRCSF | 211 | 60 | 3.5 |
| MGRM-C-026 | 269 | 70 | 3.9 |
| T332Nc | WT (T332) | ||
|---|---|---|---|
| BG505 | 63 | <40 | >1.5 |
a50 % inhibitory dilution (ID50)
bID50 of month 14 serum tested against the 92BR020 and JRCSF (both clade B) and MGRM-C-026 (clade C) viruses and their N332A mutants
cID50 of month 30 serum tested against the BG505 virus (clade A) and its T332N mutant
dThe fold-reduction in neutralization as a consequence of the lack of the N332-glycan