Fig. 6. Schematic depiction of ultrasound MLC-mediated intracellular delivery of survivin-targeted siRNA and doxorubicin.
A. PC-3 tumors, devoid of Her2 receptor, did not take up therapeutic materials even following exposure to ultrasound waves. B. LNCaP tumors, which express Her2 receptor, take up siRNA and doxorubicin into cells under exposure to ultrasound waves. Her2 = human epidermal growth factor receptor type 2, MLC = microbubble-liposome complex, siRNA = small interfering RNA