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. Author manuscript; available in PMC: 2016 Jul 7.
Published in final edited form as: J Med Chem. 2015 Sep 11;58(18):7603–7608. doi: 10.1021/acs.jmedchem.5b00935

Figure 2.

Figure 2

Structure-activity relationship of the synthesized cyclic PTs, starting from macrocycle 2. Each arrow represents a separate synthesis of a subsequent peptide embodying the modifications shown associated with the arrow. The IC50 values shown below each PT reflect the effectiveness of the resulting peptides to inhibit gp120 binding to sCD4 and 17b antibody, using SPR.