Table 1.

Demographic Information

Germline Testing Group
	LS (n = 97)		MMRD+/Lynch− (n = 70)		MMRD+/VUS (n = 31)		sporadic MSI-H (n = 55)		Total (n = 253)
	N	%	N	%	N	%	N	%	N	% p-value
Age a, b, c										<0.0001
N	97		70		31		55		253
Mean (SD)	48.3 (12.6)		51.3 (12.7)		46.2 (8.9)		60.5 (13.0)		51.5 (13.2)
Min (Med) Max	23 (48) 83		24 (50) 81		30 (46) 67		25 (60) 83		23 (50) 83
Vital Status										0.5280
Alive	79	81.4	62	88.6	28	90.3	48	87.3	217	85.8
Deceased	18	18.6	8	11.4	3	9.7	7	12.7	36	14.2
Ethnicity c										0.0402
Caucasian	77	80.2	57	81.4	18	58.1	49	89.1	201	79.8
African American	6	6.3	4	5.7	4	12.9	1	1.8	15	6.0
Hispanic	9	9.4	6	8.6	2	6.5	2	3.6	19	7.5
Asian	3	3.1	3	4.3	6	19.4	3	5.5	15	6.0
Other	1	1.0	0	0.0	1	3.2	0	0.0	2	0.8
Tumor Location										0.0476
Colon	80	82.5	58	82.9	28	90.3	40	72.7	206	81.4
Endometrial	12	12.4	12	17.1	3	9.7	15	27.3	42	16.6
Both	5	5.2	0	0.0	0	0.0	0	0.0	5	2.0
Other Cancer										0.1498
No	50	51.5	47	67.1	20	64.5	36	65.5	153	60.5
Yes	47	48.5	23	32.9	11	35.5	19	34.5	100	39.5
Number of other cancers
0	50	51.5	47	67.1	20	64.5	36	65.5	153	60.5
1	26	26.8	16	22.9	9	29.0	12	21.8	63	24.9
2	10	10.3	5	7.1	1	3.2	3	5.5	19	7.5
3 or more	11	11.3	2	2.9	1	3.2	4	7.3	18	7.1

Significant pairwise comparisons (alpha < 0.008):

^aLS vs. Sporadic MSI-H;

^bMMRD+/germline− vs Sporadic MSI-H;

^cMRD+/VUS vs. sporadic MSI-H