Table 2.
Colorectal Cancer Characteristics
| Germline Testing Group
| |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| LS (n = 85) | MMRD+/germline−(n = 58) | MMRD+/VUS (n = 28) | sporadic MSI-H (n = 40) | Total (n = 211) | p-value | ||||||
| N | % | N | % | N | % | N | % | N | % | ||
| Gender | |||||||||||
| Male | 47 | 58.8 | 28 | 48.3 | 18 | 64.3 | 13 | 32.5 | 106 | 51.5 | 0.0228 |
| Female | 33 | 41.3 | 30 | 51.3 | 10 | 35.7 | 27 | 67.5 | 100 | 48.5 | |
| Location | --+ | ||||||||||
| Ascending | 38 | 44.7 | 31 | 53.4 | 16 | 57.1 | 25 | 62.5 | 110 | 52.1 | |
| Transverse | 16 | 18.8 | 11 | 19.0 | 4 | 14.3 | 12 | 30.0 | 43 | 20.4 | |
| Descending | 12 | 14.1 | 6 | 10.3 | 4 | 14.3 | 3 | 7.5 | 25 | 11.8 | |
| Rectum | 19 | 22.4 | 10 | 17.2 | 4 | 14.3 | 0 | 0.0 | 33 | 15.6 | |
| Histology | >0.9999 | ||||||||||
| Adenocarcinoma | 84 | 98.8 | 58 | 100.0 | 28 | 100.0 | 40 | 100.0 | 210 | 99.5 | |
| Tubular adenoma | 1 | 1.2 | 0 | 0.0 | 0 | 0.0 | 0 | 0.0 | 1 | 0.5 | |
| Grade | 0.6595 | ||||||||||
| 1 | 4 | 4.9 | 2 | 3.6 | 0 | 0.0 | 2 | 5.0 | 8 | 3.9 | |
| 2 | 57 | 69.5 | 38 | 67.9 | 20 | 71.4 | 22 | 55.0 | 137 | 66.5 | |
| 3 | 21 | 25.6 | 16 | 28.6 | 8 | 28.6 | 16 | 40.0 | 61 | 29.6 | |
| Stage | --+ | ||||||||||
| I | 23 | 29.1 | 7 | 12.3 | 3 | 10.7 | 3 | 7.9 | 36 | 17.8 | |
| II | 26 | 32.9 | 21 | 36.8 | 11 | 39.3 | 14 | 36.8 | 72 | 35.6 | |
| III | 19 | 24.1 | 18 | 31.6 | 9 | 32.1 | 13 | 34.2 | 59 | 29.2 | |
| IV | 11 | 13.9 | 11 | 19.3 | 5 | 17.9 | 8 | 21.1 | 35 | 17.3 | |
| Additional Polyps a | 0.0034 | ||||||||||
| No | 35 | 53.0 | 35 | 76.1 | 20 | 90.9 | 26 | 68.4 | 116 | 67.4 | |
| Yes | 31 | 47.0 | 11 | 23.9 | 2 | 9.1 | 12 | 31.6 | 56 | 32.6 | |
| IHC (staining absent) | --+ | ||||||||||
| MLH1&PMS2* | 20 | 25.3 | 34 | 61.8 | 14 | 50.0 | 39 | 100.0 | 107 | 53.2 | |
| MSH2 & MSH6* | 38 | 48.1 | 10 | 18.1 | 8 | 28.6 | 0 | 0.0 | 56 | 27.9 | |
| PMS2 | 6 | 7.6 | 3 | 5.5 | 2 | 7.1 | 0 | 0.0 | 11 | 5.5 | |
| MSH6 | 12 | 15.2 | 5 | 9.1 | 2 | 7.1 | 0 | 0.0 | 19 | 9.5 | |
| No loss staining | 3 | 3.8 | 3 | 5.5 | 2 | 7.1 | 0 | 0.0 | 8 | 4.0 | |
| MSI | 0.0560 | ||||||||||
| High | 67 | 100.0 | 40 | 90.9 | 23 | 95.8 | 33 | 97.1 | 163 | 96.4 | |
| Low | 0 | 0.0 | 1 | 2.3 | 0 | 0.0 | 1 | 2.9 | 2 | 1.2 | |
| MSS | 0 | 0.0 | 3 | 6.8 | 1 | 4.2 | 0 | 0.0 | 4 | 2.4 | |
*
There were 21 individuals overall (5 LS, 9 MMRD+/germline−, 1 MMRD+/VUS and 6 sporadic MSI-H) who had loss of staining for MLH1 alone and 1 individual overall (MMRD+/germline−) who had loss of staining for MSH2 alone before staining for PMS2 and MSH6 was available. These individuals were incorporated into the statistics for MLH1&PMS2 and MSH2&MSH6, as they would likely have stained negative for PMS2 and MSH6 if it had been available.
Significant pairwise comparisons (alpha < 0.008):
a
LS vs. MMRD+/VUS
+
Statistical significance (alpha < 0.008) could not be established, as numerous individuals were missing this demographic characteristic