Table 5.

Safety (most frequent AEs related to REG clinical use) (FAS population, n = 654)

Adverse events	Any Grade N (%)	Grade 3–4 N (%)
Any event	524 (80.1)	286 (43.7)
Fatigue	271 (41.4)	95 (14.5)
Hand and Food Skin Reactions	189 (28.9)	59 (9)
Diarrhea	123 (18.8)	28 (4.3)
Anorexia	96 (14.7)	19 (2.9)
Hypertension	72 (11)	30 (4.6)
Mucositis	72 (11)	8 (1.2)
Weight loss	33 (5)	4 (<1)
Rash or desquamation	26 (4)	8 (1.2)
Thrombopenia	21 (3.2)	1 (<1)
Muscle pain	9 (1.4)	1 (<1)
Proteinuria	8 (1.2)	2 (<1)
Hyperbilirubinemia	7 (1.1)	0