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. Author manuscript; available in PMC: 2016 Jul 7.
Published in final edited form as: Nature. 2016 Jan 13;529(7586):351–357. doi: 10.1038/nature16478

Figure 1. A novel functional genomic mouse model of recurrent Shh medulloblastoma using microneurosurgical resection and computed-tomography-guided multi-fractionated craniospinal radiotherapy.

Figure 1

a, Ptch+/−/Math1-SB11/T2Onc mice with medulloblastoma underwent subtotal tumour removal (n = 38) and received multi-fractionated CSI post-operatively. Radiation was delivered under computed tomography (CT) guidance. b, Microneurosurgery and CSI strikingly improves tumour-free survival as compared to untreated controls (P = 0.0001, log-rank test, n = 64). Inset schematic indicates the fractionation schedule. c, Venn diagrams demonstrate the paucity of overlap in the gCISs between primary tumours and their recurrences. d, Drosophila brain tumours harbouring wild-type P53 displayed massive apoptosis in response to 40 Gy irradiation. e, Dominant negative P53 (p53R159N) essentially abrogated the radiation-dependent cell death. Scale bar, 50 µm.