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. Author manuscript; available in PMC: 2016 Jul 7.
Published in final edited form as: Nature. 2016 Jan 13;529(7586):351–357. doi: 10.1038/nature16478

Extended Data Figure 10. Genetic events in recurrent human medulloblastoma converge on specific signalling pathways.

Extended Data Figure 10

a, Copy number profile of MB-REC-12 therapy-naive (WT, green, left panel) and recurrent tumour (loss, blue, lower panel), showing recurrence-specific loss of chr14q. b, DYNC1H1 expression is reduced in Shh patients with chr14q loss (n = 18/80, Mann–Whitney test, P < 0.0001, centre lines show the medians; box limits indicate the 25th and 75th percentiles; whiskers extend 1.5 times the interquartile range from the 25th and 75th percentiles). c, Expression of the chr14 signature genes discriminating between chr14q balanced (n = 34) and chr14q loss (n = 18) in the Boston cohort of Shh medulloblastoma samples.