Extended Data Figure 3. Subclonal events in primary human tumours become clonal at recurrence.

The proportion of somatic SNVs in the primary and recurrent disease compartments of 15 patients with matched germline is shown as a function of clonality. Black indicates homozygous events, purple indicates clonal SNVs, and subclonal SNVs are shown in green, where lighter shades correspond to less abundant subpopulations. On average, we observe a 1.9-fold increase in the proportion of clonal and homozygous events across the cohort (Student’s t-test; P value = 8.7 × 10⁻³, n = 15).