Fig. 2.

Schematic diagram of the BRAF. a Schematic diagram of the BRAF shows the rare, somatic, non-hot spot, mutations of BRAF gene in exon 15 at various nucleotide positions, numbers in the boxes indicate exons and boxes indicate various domains: RBD-ras binding domain, CRD-cysteine rich domain, KD-kinase domain, L–G loop, a conserved glycine motif. b A diagram of native modeled structure of BRAF homodimer. Each monomer molecule is indicated in different color (red and green). The structure of BRAF protein in complex PDB ID is 4E26. Amino acid residues of rare, non-hotspot, somatic mutation identified in adult differentiated thyroid cancer are plotted in BRAF native protein structure using SWISS PDB viewer and the mutated residues are shown in sphere shape. c Shows the monomer cartoon diagram of native modeled structure of BRAF kinase domain. The structure of BRAF protein kinase domain (monomer) PDB ID is 4WO5. Amino acid residues of rare, non-hotspot, somatic mutation identified in adult differentiated thyroid cancer are plotted in BRAF native protein structure and the molecule is visualized by JSmol