Table 4.
Comparison of clinical and histopathological characteristics between patients with positive and negative BRAF V600E mutation in adult DTCs
| Characteristics | BRAF V600E mutation | BRAF wild type | P value |
|---|---|---|---|
| (95 cases) | (105 cases) | ||
| Age mean ± SD (years) | 43.5 ± 15 | 36.2 ± 13.3 | 0.0001* |
| Sex (female:male) | 71:24 | 79:26 | 1.00 |
| Tumor size | 3.05 ± 1.97 | 3.31 ± 2.43 | 0.42 |
| Tumor multifocality | 49 (51.6 %) | 48 (45.7 %) | 0.49 |
| Extrathyroidal invasion | 54 (56.8 %) | 41 (39 %) | 0.017* |
| Lymph node metastasis | 51 (53.7 %) | 40 (38.1 %) | 0.038* |
| Distant metastasis | 6 (6.3 %) | 9 (8.6 %) | 0.74 |
| TNM stage III/IV | 31 (32.6 %) | 13 (12.4 %) | 0.001* |
| Persistent disease (6–12 months after initial management) | 47 (49.5 %) | 43 (40.96 %) | 0.29 |
| Persistent/recurrent disease (At last follow up) | 37 (38.9 %) | 30 (28.6 %) | 0.16 |
* Statistically significant