Table 1.

Brain regions showing significant differences between rapist and control subjects, illustrating clusters in which rapists had reduced and increased white matter fractional anisotropy compared with control subjects

Cluster size (mm3)	MNI coordinates (mm)			Anatomical location		FA (Mean ± SD)		T score	p value	Cohen’s d
	x	y	z	White matter tract	Brain region	Control	Offender
Decreased FA in sex offenders versus controls
18	−35	−82	16	Inferior fronto-occipital fasciculus	Lateral occipital lobe, Middle occipital gyrus	0.42 ± 0.06	0.32 ± 0.03	5.55	0.0000	2.11
13	21	−43	0	Posterior cingulum	Parahippocampul gyrus	0.59 ± 0.05	0.50 ± 0.04	5.05	0.0001	1.99
10	52	−39	23	Superior longitudinal fasciculus	Inferior parietal lobule, or Supramarginal gyrus	0.54 ± 0.05	0.45 ± 0.05	4.26	0.0001	1.80
10	25	−35	−10	Posterior cingulum	Parahippocampul gyrus	0.60 ± 0.07	0.52 ± 0.05	3.39	0.0071	1.32
Increased FA in sex offenders versus controls
29	−16	33	11	Genu		0.55 ± 0.05	0.63 ± 0.06	4.08	0.0001	1.45
17	12	8	1	Internal capsule (anterior thalamic radiation)	Caudate	0.62 ± 0.05	0.71 ± 0.04	4.45	0.0002	1.99
16	−25	−69	26		Lateral occipital lobe (superior division)	0.48 ± 0.05	0.56 ± 0.05	4.11	0.0002	1.60
16	18	−10	−3	Poterior limb of internal capsule	Globus pallidus	0.70 ± 0.05	0.76 ± 0.04	4.16	0.0003	1.33
14	24	−46	3	Posterior cingulate	Posterior cingulate	0.34 ± 0.09	0.46 ± 0.07	3.88	0.0028	1.49
14	−6	51	−18	Forceps minor	Medial frontal pole	0.23 ± 0.03	0.32 ± 0.07	4.06	0.0001	1.67
12	−7	−81	29	Forceps major	Cunerus	0.24 ± 0.04	0.33 ± 0.06	4.47	0.0002	1.77
11	42	−51	37	Superior longitudinal fasciculus	Supramarginal, or Angular gyrus	0.38 ± 0.09	0.51 ± 0.07	4.18	0.0006	1.61
10	−13	0	4	Internal capsule (anterior thalamic radiation)	Caudate	0.63 ± 0.05	0.71 ± 0.06	3.83	0.0025	1.45
10	−11	−5	−10	Posterior limb of internal capsule	Lower thalamus	0.69 ± 0.04	0.76 ± 0.05	3.37	0.0013	1.55

Covariate: age