Table 1.
Clinical characteristics of LBBB patients by obesity in MADIT-CRT
| Non-obese n = 833 | Obese n = 431 | p value | |
|---|---|---|---|
| Demographics | |||
| Age, mean ± SD, y | 65.8 ± 10.6 | 61.1 ± 10.6 | <0.001 |
| Women, n (%) | 263 (32) | 125 (29) | 0.348 |
| White n (%) | 764 (92) | 389 (90) | 0.272 |
| Cardiac history n (%) | |||
| CRT-D assigned n (%) | 498 (60) | 259 (60) | 0.915 |
| Ischemic cardiomyopathy | 374 (45) | 183 (42) | 0.408 |
| Diabetes | 216 (26) | 166 (39) | <0.001 |
| Hypertension | 497 (60) | 300 (70) | <0.001 |
| Prior MI | 268 (33) | 135 (32) | 0.761 |
| Prior CABG | 191 (23) | 90 (21) | 0.401 |
| Prior HF hospitalization | 310 (38) | 172 (40) | 0.421 |
| Past atrial arrhythmias | 93 (11) | 47 (11) | 0.892 |
| Past ventricular arrhythmias | 47 (6) | 34 (8) | 0.121 |
| Clinical characteristics at enrolment mean ± SD | |||
| LVEF (%) | 28.9 ± 3.5 | 28.5 ± 3.4 | 0.132 |
| QRS duration (ms) | 162.1 ± 19.3 | 164.7 ± 19.0 | 0.012 |
| Resting heart rate (bpm) | 67.7 ± 10.9 | 69.2 ± 10.9 | 0.019 |
| Systolic blood pressure (mmHg) | 122.2 ± 17.2 | 123.6 ± 17.0 | 0.090 |
| Diastolic blood pressure (mmHg) | 70.7 ± 9.9 | 72.9 ± 10.7 | 0.002 |
| Brain natriuretic peptide pg/dl | 134.8 ± 168.9 | 78.7 ± 91.9 | <0.001 |
| Glomerular filtration rate ml/m2 | 68.5 ± 19.8 | 70.8 ± 20.4 | 0.046 |
| Medications, n (%) | |||
| ACE inhibitor or aldosterone receptor antagonists | 797 (96) | 418 (97) | 0.254 |
| Aldosterone receptor antagonists | 254 (30) | 172 (40) | <0.001 |
| Aspirin | 500 (60) | 275 (64) | 0.191 |
| Beta-blockers | 779 (94) | 408 (95) | 0.419 |
| Diuretic | 536 (64) | 328 (76) | <0.001 |
| Statins | 522 (63) | 281 (65) | 0.375 |
| ICD programming | |||
| Rate of lowest VT <180 bpm | 153 (20) | 63 (16) | 0.060 |
| Rate of highest VF >210 bpm | 79 (10) | 45 (10) | 0.650 |
| ATP (%) | 743 (91) | 399 (93) | 0.267 |
| Cut-off rate of lowest VT zone (ms) | 177 ± 7 | 178 ± 7 | 0.029 |
| Cut-off rate of VF zone (ms) | 209 ± 9 | 210 ± 8 | 0.357 |