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. 2016 Jul 7;17:46. doi: 10.1186/s12868-016-0281-8

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© The Author(s) 2016

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 1 — a Southern blot analysis of the genomic DNA of the founder animals used to determine the copy number of PS1 transgene. The copy number of the PS1 transgene was determined by the number of hybridized genomic DNA segments in the autoradiogram and is shown in parenthesis above the rat numbers. M represents the molecular weight (MW) markers. b Serum Aβ₄₂/Aβ₄₀ levels of APP + PS1 double transgenic founder animals and APP21 rats at 8 weeks of age. The Aβ₄₂/Aβ₄₀ ratio for rat 988 could not be determined because its Aβ₄₂ level was lower than the detection limit of the test. Founder 964 was selected based on having one PS1 transgene and high Aβ₄₂/Aβ₄₀ levels as well as for having a large litter with high Aβ₄₂/Aβ₄₀ levels