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. 2016 Jul 7;17:46. doi: 10.1186/s12868-016-0281-8

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© The Author(s) 2016

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 2 — PS1 expression in founder animals and APP controls as determined by Northern blot analysis. The expression of PS1 was analyzed by combining animals with similar serum Aβ₄₂ levels and statistical analysis conducted for each tissue. The figure legend indicates the range of serum Aβ₄₂ level (pg/ml) of the founder animals or the APP control rats. Different letters above each bar indicates significantly different (p < 0.05) expression