Table 3.
Odds ratios (OR) with 95 % confidence intervals (CI) between lung cancer and transition in time-weighted average occupational social prestige categories for first occupation to last occupation and first occupation to longest occupation
| Transitions in social prestige categories a | Cases [N] | Controls [N] | OR1 b (95 % CI) | OR2 c (95 % CI) | OR3 d (95 % CI) | OR4 e (95 % CI) | |
|---|---|---|---|---|---|---|---|
| Change in social prestige from first to last occupation | |||||||
| Consistent | H to H | 1,088 | 2,333 | 1.0 | 1.0 | 1.0 | 1.0 |
| M to M | 1,796 | 2,106 | 1.71 (1.55–1.88) | 1.40 (1.25–1.56) | 1.37 (1.23–1.53) | 1.20 (1.06–1.35) | |
| L to L | 3,960 | 3,567 | 2.29 (2.10–2.50) | 1.63 (1.48–1.80) | 1.57 (1.42–1.74) | 1.31 (1.17–1.45) | |
| Downward | H to L | 168 | 210 | 1.70 (1.37–2.11) | 1.33 (1.03–1.71) | 1.28 (0.99–1.65) | 1.13 (0.88–1.46) |
| H to M | 144 | 244 | 1.20 (0.96–1.49) | 1.03 (0.81–1.32) | 1.03 (0.80–1.32) | 0.95 (0.74–1.22) | |
| M to L | 1,386 | 1,303 | 2.08 (1.87–2.31) | 1.52 (1.34–1.71) | 1.46 (1.29–1.65) | 1.24 (1.08–1.41) | |
| Upward | M to H | 963 | 1,781 | 1.04 (0.93–1.16) | 0.94 (0.83–1.07) | 0.93 (0.82–1.05) | 0.87 (0.77–0.99) |
| L to H | 832 | 1,451 | 1.15 (1.03–1.29) | 0.94 (0.83–1.07) | 0.92 (0.81–1.05) | 0.83 (0.73–0.95) | |
| L to M | 1,096 | 1,152 | 1.88 (1.68–2.10) | 1.45 (1.28–1.65) | 1.40 (1.23–1.59) | 1.19 (1.04–1.36) | |
| Change in social prestige from first occupation to longest occupation | |||||||
| Consistent | H to H | 1,155 | 2,417 | 1.0 | 1.0 | 1.0 | 1.0 |
| M to M | 2,154 | 2,497 | 1.69 (1.54–1.85) | 1.38 (1.24–1.53) | 1.35 (1.21–1.50) | 1.17 (1.05–1.31) | |
| L to L | 4,108 | 3,799 | 2.18 (2.0–2.38) | 1.57 (1.42–1.73) | 1.51 (1.37–1.66) | 1.26 (1.13–1.40) | |
| Downward | H to L | 123 | 155 | 1.63 (1.27–2.10) | 1.22 (0.91–1.62) | 1.17 (0.88–1.56) | 1.02 (0.77–1.37) |
| H to M | 122 | 215 | 1.10 (0.87–1.39) | 0.93 (0.72–1.21) | 0.93 (0.71–1.21) | 0.85 (0.65–1.11) | |
| M to L | 1,157 | 1,092 | 2.0 (1.79–2.23) | 1.43 (1.27–1.63) | 1.38 (1.22–1.57) | 1.16 (1.01–1.32) | |
| Upward | M to H | 834 | 1,601 | 0.97 (0.86–1.08) | 0.90 (0.80–1.02) | 0.89 (0.79–1.01) | 0.84 (0.74–0.96) |
| L to H | 724 | 1,260 | 1.11 (0.99–1.25) | 0.92 (0.81–1.05) | 0.90 (0.79–1.03) | 0.82 (0.71–0.94) | |
| L to M | 1,056 | 1,111 | 1.83 (1.63–2.04) | 1.40 (1.23–1.59) | 1.35 (1.18–1.53) | 1.14 (0.99–1.31) | |
a Categories for occupational social prestige scores according to tertiles among control subjects: Low (L) = 13- ≤ 35, Medium (M) = >35- ≤ 45, and High (H) = >45–78 points
b Odds ratios for model 1 are adjusted for study center and log(age)
c Odds ratios for model 2 are additionally adjusted for smoking status with time since quitting (2–7, 8–15, 16–25 or ≥26 years before interview/diagnosis, other types of tobacco only, non-smokers), and log(pack-years + 1)
d Odds ratios for model 3 are additionally adjusted for ever working in “List A” occupation
e Odds ratios for model 4 are additionally adjusted for highest education