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. 2016 Jul 7;16:393. doi: 10.1186/s12885-016-2418-7

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© The Author(s). 2016

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 5 — Combination effects of AR-A014418 and rapamycin in ACHN cells. a ACHN cells were treated with AR-A014418 and rapamycin as single agents or their combination at different concentration at a constant dilution ratio of 25,000 : 1. Cell viability was assessed using MTS assay after 72 h incubation. Data are the mean ± SD in each bar-plot from four replicates of ACHN cells at each concentration. b Effects of the drug combination was demonstrated on a Fa-CI plot generated using CompuSyn. Combination index (CI) determines the type of drug interaction as follows: additive, synergistic, or antagonistic if CI is 1, < 1 or > 1, respectively [26]. The combination effects varied from additivity to antagonism according to the increase in drug concentration