Table 3.
Pathways with enriched mRNA targets potentially influenced by A. butzleri-induced miRNAs
| Pathway | miRNAs | mRNA targets | p value |
|---|---|---|---|
| Endocytosis | miR-30d-3p | SH3GL3, DNM3, FLT1, ERBB4, STAM2, VTA1, PRKCI, ARF6, HLA-B, KIT, ZFYVE20, RAB31, AP2B1, RAB11FIP2, CHMP1B, RAB22A, RAB11B, VPS36, RNF41 | 0.063 |
| miR-30d-5p | NEDD4, ACAP2, RAB11A, EEA1, NEDD4L, KIT, ARAP2, CHMP2B | 0.085 | |
| Apoptosis/p53 signaling pathway | miR-3613 | CDK6, RRM2B, ATR, SESN3 | 0.037 |
| miR-2116 | IRAK2, IRAK1, IRAK3, PRKAR2A, DFFA, PIK3CB, CASP8, CHP2, EXOG, PPP3R2, PIK3R1 | 0.076 | |
| EI24, CD82, RRM2, SERPINE1, CASP8, RCHY1, RRM2B, MDM4, PERP, CDK2, SESN3 | 0.017 | ||
| Regulation of actin cytoskeleton | miR-30d-3p | GNA13, FGF7, PIK3CB, ROCK2, DIAPH2, SSH2, GNA12, ITGA1, ACTN2, PPP1CB, NCKAP1, DOCK1, CHRM2, TIAM1, SOS1, SOS2, WASL, CRK, FGF2, MYLK, APC | 0.079 |
| MAPK signaling pathway | miR-671 | RASGRF1, FGF11, CACNB3, FGF1, CRK | 0.063 |
| miR-30d-5p | MAP3K7, CASP3, MAP3K5, TAOK1, MAP3K2, PLA2G12A, NF1, PLA2G2C, PPP3CA, FGF20 | 0.099 | |
| Formation of immunoproteasome | miR-629 | PSMA2, PSMB10, PSMD13, PSMB2, PSME4 | 0.023 |