Table 2.
Patients | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 |
Age (yr)1 | 68 | 53 | 68 | 63 | 80 | 40 | 83 | 55 | 67 | 72 |
Sex | Male | Male | Male | Female | Male | Female | Female | Female | Female | Female |
Ethnicity | Pacific Islander | Indian | European | Pacific Islander | Pacific Islander | Pacific Islander | Pacific Islander | Pacific Islander | European | European |
Metformin dose (g/d) | 2.5 | 1.7 | 2 | 3 | 2 | 2 | 1 | 2 | 1.7 | 1 |
Duration of Metformin2 | 5 yr | 4 yr | 5 yr | 4 yr | 2 yr | 1 yr | 4 yr | 4 yr | 4 yr | 2 mo |
Baseline Creatinine (μmol/L) | 114 | 57 | 138 | 123 | 106 | 123 | 180 | 105 | 154 | 139 |
3eGFR mL/min per 1.73 m2 | 55 | 130 | 44 | 38 | 58 | 42 | 23 | 47 | 29 | 32 |
Creatinine at Presentation (μmol/L) | 449 | 90 | 333 | 612 | 381 | 612 | 376 | 895 | 973 | 304 |
pH | 7.3 | 7.23 | 7.14 | 7.32 | 6.99 | 7.21 | 7.34 | 6.9 | 7.35 | 7.09 |
Bicarbonate (mmol/L) | 15 | 13 | 13 | 16 | 6 | 12 | 12 | 3 | 15 | 15 |
Lactate (mmol/L) | 9.2 | 6.7 | 15 | 6 | 16 | 8.4 | 6 | 22 | 6.2 | 7 |
Received acute haemodialysis | Yes | No | Yes | No | No | No | No | No | Yes | No |
Outcome | Dead | Alive | Alive | Alive | Dead | Alive | Alive | Alive | Alive | Alive |
Creatinine at discharge (μmol/L) | - | 73 | 121 | 95 | - | 90 | 167 | 123 | 129 | 96 |
3eGFR mL/min per 1.73 m2 | - | 97 | 52 | 52 | - | 60 | 25 | 39 | 36 | 50 |
The age of the patient is rounded down to the nearest year;
The duration of metformin is rounded down to completed years of therapy, except for patient 10;
eGFR: The estimated glomerular filtration rate based on the four variable MDRD formula[12]. eGFR: Estimated glomerular filtration rate; MDRD: Modification of diet in renal disease.