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. 2016 Jul 6;5(4):367–371. doi: 10.5527/wjn.v5.i4.367

Table 2.

Demographic and clinical details of patients with metformin associated lactic acidosis

Patients 1 2 3 4 5 6 7 8 9 10
Age (yr)1 68 53 68 63 80 40 83 55 67 72
Sex Male Male Male Female Male Female Female Female Female Female
Ethnicity Pacific Islander Indian European Pacific Islander Pacific Islander Pacific Islander Pacific Islander Pacific Islander European European
Metformin dose (g/d) 2.5 1.7 2 3 2 2 1 2 1.7 1
Duration of Metformin2 5 yr 4 yr 5 yr 4 yr 2 yr 1 yr 4 yr 4 yr 4 yr 2 mo
Baseline Creatinine (μmol/L) 114 57 138 123 106 123 180 105 154 139
3eGFR mL/min per 1.73 m2 55 130 44 38 58 42 23 47 29 32
Creatinine at Presentation (μmol/L) 449 90 333 612 381 612 376 895 973 304
pH 7.3 7.23 7.14 7.32 6.99 7.21 7.34 6.9 7.35 7.09
Bicarbonate (mmol/L) 15 13 13 16 6 12 12 3 15 15
Lactate (mmol/L) 9.2 6.7 15 6 16 8.4 6 22 6.2 7
Received acute haemodialysis Yes No Yes No No No No No Yes No
Outcome Dead Alive Alive Alive Dead Alive Alive Alive Alive Alive
Creatinine at discharge (μmol/L) - 73 121 95 - 90 167 123 129 96
3eGFR mL/min per 1.73 m2 - 97 52 52 - 60 25 39 36 50
1

The age of the patient is rounded down to the nearest year;

2

The duration of metformin is rounded down to completed years of therapy, except for patient 10;

3

eGFR: The estimated glomerular filtration rate based on the four variable MDRD formula[12]. eGFR: Estimated glomerular filtration rate; MDRD: Modification of diet in renal disease.