FIG 4.

Kinetics of dissemination of leptospires in tissues from a hamster infected with 10⁸ leptospires of strain Fiocruz L1-130 comparing the i.p. and CJ routes of infection. The bacterial load for each tissue was calculated based on the mean result for two perfused hamsters for each time point. Each line represents the mean (logarithmic scale) of two independent experiments. The error bars represent the standard deviations. Animals infected by the i.p. route (straight lines) were analyzed after 1 and 4 days postinfection. Animals infected by the CJ route of infection (dashed lines) were analyzed 1, 4, and 7 days postinfection.