TABLE 1.

Analysis of major histopathological alterations in hamsters infected with 10⁸ or 2.5 × 10² leptospires according to days postinfection for each dose of inoculum

Tissue and histopathology	Resulta
	108 leptospires i.p.				2.5 × 102 leptospires i.p.
	Control	Day postinfection			Control	Day postinfection
		1	3	4		5	8	12
Kidney
Hemorrhage	0, 0, 0	0, 0, 0	1, 1, 0	0, 0, 0	1, 1, 1	1, 0, 2	1, 0, 1	0, 0, 0
Inflammation	0, 0, 0	0, 0, 0	0, 0, 0	1, 0, 0	0, 0, 0	0, 0, 0	0, 0, 1	0, 0, 1
Hyaline degeneration	0, 2, 1	1, 1, 0	0, 1, 1	1, 1, 1	1, 1, 1	2, 2, 2	2, 3, 3	2, 2, 1
Hydropic degeneration	0, 0, 0	0, 0, 1	0, 0, 0	1, 1, 1	0, 0, 0	0, 0, 0	0, 1, 1	3, 1, 3
Cylinders	1, 1, 1	0, 0, 0	0, 1, 1	1, 1, 0	1, 1, 0	1, 1, 0	2, 1, 2	1, 0, 1
Liver
Hydropic degeneration	0, 0, 0	0, 0, 0	0, 0, 0	0, 0, 0	0, 0, 0	0, 0, 0	2, 2, 0	0, 0, 0
Infiltrating mononuclear cells	0, 0, 0	0, 0, 0	0, 0, 0	1, 0, 0	1, 0, 0	0, 0, 0	1, 0, 0	1, 0, 0
Necrosis	0, 0, 0	0, 0, 0	0, 0, 1	0, 0, 1	0, 0, 0	0, 0, 0	0, 0, 1	0, 0, 0
Steatosis	0, 0, 0	0, 0, 0	2, 1, 0	2, 1, 1	0, 0, 0	0, 0, 0	0, 1, 0	2, 1, 1
Loss of parenchymal architecture	0, 0, 0	2, 2, 1	0, 0, 0	0, 0, 0	0, 0, 1	2, 2, 2	2, 3, 3	1, 1, 1
Lung
Alveolar hemorrhage	0, 0, 0	0, 0, 0	1, 2, 2	1, 2, 1	0, 0, 0	0, 0, 0	0, 2, 1	3, 2, 2
Bronchial hemorrhage	0, 0, 0	0, 0, 0	1, 1, 0	1, 1, 1	0, 0, 0	1, 0, 0	1, 1, 1	1, 1, 1
Alveolar congestion	0, 0, 0	0, 0, 0	1, 1, 0	2, 1, 1	0, 0, 0	0, 0, 1	1, 1, 1	2, 2, 1
Septal thickening	0, 0, 0	1, 1, 1	1, 1, 0	1, 1, 1	0, 0, 0	1, 1, 1	1, 1, 1	1, 1, 0

^aThe results are shown as scores for 3 randomly chosen animals analyzed individually on each day. For comparison and analysis, the semiquantitative ranking was transformed into numbers: negative, 0; discrete, 1; mild, 2; and intense, 3.