FIG 3.
Infected Chil1-expressing mice have less pulmonary injury and improved host health during PA103 infection. WT and Chil1-deficient mice were infected with 105 CFU of PA103. BAL fluid was collected, and temperature and weight loss were measured at the times indicated. (A and B) Infected Chil1-deficient mice had increased pulmonary injury, as assessed by BAL hemorrhage (A) and BAL fluid protein recovery (B). PA, P. aeruginosa. (C and D) Infected Chil1-deficient mice had more weight loss compared to their preinfection weight than infected WT mice (C), while temperature changes from baseline were similar in the two groups (D). Cont, control. *, P < 0.05; NS, not significant. The data represent three independent experiments with 8 to 10 mice per group. The error bars indicate SEM.