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. Author manuscript; available in PMC: 2016 Jul 7.
Published in final edited form as: Alcohol Clin Exp Res. 2016 May 5;40(6):1251–1261. doi: 10.1111/acer.13060

Figure 1.

Figure 1

Chronic ethanol exposure induces bidirectional changes in the expression of NMDA and Kv4.2 receptors in the hippocampus. (A) In an in-vivo model of chronic intermittent ethanol exposure (CIE), immunoblot analysis of the expression of GluN1 and GluN2B in the hippocampus was significantly increased when measured immediately following the last episode of ethanol exposure. In contrast, expression of Kv4.2 and KChIP3 was significantly reduced (n = 9-11). (B) Nearly identical bidirectional changes in response to chronic ethanol (75 mM) exposure were obtained in organotypic hippocampal slice cultures (n= 7). Values represent mean ± SEM, * p < 0.05.